Table of Contents Guard Against the Drug-Induced CoQ10 Deficiency That Can Weaken Your Heart. Your body needs Coenzyme Q10 to ensure the health of virtually all tissues and organs.\u00a0 In fact, most cellular functions depend on CoQ10 for their energy production (ATP synthesis). Scientific studies continue to highlight the importance of maintaining adequate CoQ10 levels. For example.\u00a0 \tCoQ10 levels decline with advancing age, and this decline might contribute to some manifestations\u00a0of aging. \tSusceptibility to CoQ10 deficiency appears to be greatest in the\u00a0heart,\u00a0brain, and\u00a0immune system. \tCoenzyme Q10 is especially important for\u00a0cardiovascular health. \tAny deficit in CoQ10 will cause\u00a0disorders in energy production\u00a0and result in\u00a0cell damage. Unfortunately, a class of widely-prescribed cholesterol-lowering drugs known as \u201cstatins\u201d have been shown to block the body\u2019s synthesis of CoQ10. In fact, controlled studies show that\u00a0statins can reduce blood plasma levels of Coenzyme Q10 by up to 50%. World\u2019s Most Widely Prescribed Drugs Deplete Coenzyme Q10 Statins are among the most widely prescribed medicines in the world. Furthermore, the world\u2019s top-selling drug is a statin drug with annual sales of $12.9 billion. In 2001, major revisions of the U.S. guidelines increased the number of Americans for whom statins were recommended from 13 million to 36 million. \u00a0Then, in a recent update, cholesterol-lowering guidelines were published which were even more aggressive. Just one week after these recommendations were published, however, it was revealed that eight of the nine authors of the new cholesterol guidelines had financial ties to statin drug makers. Such conflicts of interest have prompted consumer groups and several leading health experts to question the advice of panelists who failed to disclose their income from these statin drug companies. One such health expert, Dr. John Abramson, MD of Harvard Medical School, says that putting millions of additional Americans on statin drugs flies in the face of sound science. This award-winning physician explains that although statins may, in fact, have benefits in certain high-risk individuals, there is little evidence to support their widespread use in people without evident occlusive vascular disease. In fact, as one consumer group pointed out, exercising, eating a healthy diet, and not smoking each individually appear to give more protection against heart disease , as well as the added benefit of preventing diabetes, osteoporosis, and multiple other diseases. Dr. Abramson and Dr. Jim Wright of the University of British Columbia have recently co-authored a landmark article entitled Are Lipid-Lowering Guidelines Evidence-Based?, published in the issue of the prestigious British medical journal The Lancet. Problems Associated with Low CoQ10 Levels Low levels of Coenzyme Q10 are associated with impaired heart function, liver dysfunction, and muscle disorders, including cardiomyopathy and congestive heart failure. \u00a0As reported in expert reviews, the lowering of CoQ10 can have a significantly harmful effect in patients with cardiovascular diseases; however, this may be controlled by oral supplementation. Muscle problems are the most common reported adverse effects of statins. And perhaps the most feared adverse effect of statins is rhabdomyolysis a rare condition in which there is a severe breakdown of muscle tissue that may be toxic to the kidneys and result in kidney failure or death. Supplemental CoQ10 Helps Restore Cellular Energy Production A 2007 study found that 100 mg a day of supplemental CoQ10 decreased muscle pain associated with statin treatment. The study\u2019s authors concluded that Coenzyme Q10 supplementation may offer an alternative to stopping appropriate treatment with statin drugs. Furthermore, in clinical research, a combination of statins and CoQl0 induced a more pronounced effect on the total cholesterol\/HDL cholesterol ratio. Although not highly publicized, statin drugs' adverse effects on CoQ10 levels have long been known. In fact, one of the world\u2019s largest statin drug manufacturers holds patents on the combination of CoQ10 and statins. These patents refer to supplemental CoQ10\u2032s ability to counteract the adverse effects of statins on Coenzyme Q10 levels in the human body. Moreover, the American Medical Association\u2019s Archives of Neurology has published a report stating, widespread inhibition of CoQl0 synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, myalgia, and myoglobinuria. \u00a0(Myoglobinuria is associated with a breakdown of muscle cells, impaired kidney function, kidney failure, and heart arrhythmias.) A Truly Life-Saving Approach to Heart Health According to a team of British researchers, a decline in tissue CoQ10 has\u2026been implicated in aging, which would make the elderly more susceptible to statin-induced CoQ10 depletion.\u201d It is, therefore, essential that prescribing physicians and patients be aware that statin drugs may impair skeletal muscle and heart energy due to depleted Coenzyme Q10 levels. A study that appeared in Archives of Neurology reported that even brief exposure to atorvastatin (Lipitor) causes a marked decrease in blood CoQ10 concentration.\u201d The study\u2019s authors concluded that \u201c\u2026it may be reasonable to add CoQ10 in patients receiving long-term treatment with statins in general, and atorvastatin in particular. This recommendation is strengthened by the general experience that oral CoQ10\u2014even in high doses \u2013is well tolerated by patients. Until recently, so-called \u201chealth experts\u201d within mainstream medicine have unwaveringly supported the widespread use of statins. Some even jokingly suggested that statins should be added to the public water supply!\u00a0 Then Reuters News Service published an article entitled \u201d Study Casts Doubt on Universal Statin Use. \u00a0This article reported on a major study published in the Archives of Internal Medicine\u00a0showing that\u00a0statin drugs do little to reduce the risk of death in people with no history of cardiovascular disease.\u00a0 Ironically, the same \u201cexperts\u201d who arbitrarily recommend statin drugs to millions of Americans have failed to recommend supplemental CoQ10 in spite of its safety and potential benefits. What\u2019s the smartest approach to using statins? According to cardiologist Peter H. Langsjoen, M.D., one of the world\u2019s leading experts on CoQ10: \u201cStatin-induced CoQ10 deficiency is\u00a0completely preventable\u00a0with supplemental CoQ10, with no adverse impact on the cholesterol-lowering or anti-inflammatory properties.\u201d Faq About CoQ10 \t What are the symptoms of low CoQ10? Even as everybody is different, people who have a shortage in\u00a0CoQ10\u00a0levels often involvement physical fatigue and muscle faintness, even though undertaking comparatively non-strenuous physical activities such as walking. \t Who should not take CoQ10? People with chronic diseases such as heart failure, kidney or liver complications, or diabetes\u00a0must\u00a0be wary of consuming this supplement.\u00a0CoQ10\u00a0may lower blood sugar levels and blood pressure. \t Is CoQ10 really necessary? Coenzyme Q10\u00a0(CoQ10), a nutrient twisted by the body and used for cellular energy, is often plugged as being vital if you're using statin drugs to lower cholesterol level. User of\u00a0CoQ10\u00a0say it helps decrease muscle pain, which can be a side effect of statin use, and is an important energy source that the body needs. \t Can low CoQ10 cause anxiety? As with other supplements that enhance energy levels,\u00a0CoQ10\u00a0Proponents\u00a0have reported\u00a0side effects\u00a0such as headaches, minor stomach upset, feeling nervous or \u201cstrengthened,\u201d and feeling mild insomnia. Other\u00a0side effects\u00a0reported less often include palpitations,\u00a0anxiety, dizziness, irritability, and rarely, rashes.