Parkinson's Disease Definition: Parkinson's Disease was first described in 1817 by James Parkinson. It is a common disorder of the brain. In Parkinson's Disease, certain brain cells called neurons deteriorate. The exact reason for this process is not known. These neurons are important because they produce a substance called dopamine. Dopamine is a chemical "messenger" in the brain that helps the nervous system control muscle activity. When these neurons are destroyed dopamine is not produced at the normal rate 01. Parkinson's Disease belongs to a group of conditions called Motor System Disorders. An abnormally low supply of dopamine causes Parkinson's symptoms to appear. Parkinson's Disease Symptoms \tthe commonest symptoms are involuntary tremors (shaking) and slowness of movement. The tremor activity is usually decreased by action and increasing by emotion. These tremors usually occur on both sides or can be more prominent on one side of the body. The characteristic of slowness and decrease of voluntary movement can be attributed to neuronal degeneration from unknown causes. \tRigidity is the result of stiffness to the limbs, referred to as "lead-pipe" rigidity which is usually prominent on one side. The phenomenon 'cogwheeling' results from the simultaneous movement of the opposite limb increasing the tone of the tremor causing a jerky resistance to passive movement. \tFacial features are expressionless and Stoney, conveying the patient's cold lifeless emotions. Speech is altered to a hurried monotonous slurring. Dribbling is uncontrolled, due to the difficulty in swallowing that occurs as the disease progresses. \tPostural changes occur, causing a characteristic stooped position and a shuffling gait. This type of postural change is referred to as 'simian', which describes the forward flex of the spine, immobility of the arms, and facial features. Balance is impaired and sitting position is characterized by the torso bent forward and motionless. Parkinson's Disease Stages Additional symptoms include constipation, urinary difficulties, skin is oily, sweating is excessive and dementia is common in the later stages. In Summary the primary and secondary symptoms: The primary symptoms include: \tstiffness of limbs and trunk, \ttremor of hands, arms, legs, jaw, and face \tslowness and poverty of movement \tdifficulty with balance, \tand difficulty in walking. Secondary symptoms of include: \tdepression \tsenility \tpostural deformity \tdifficulty in speaking. Parkinson's Syndrome, or Atypical Parkinson's There are some other neurological disorders that may have both primary and secondary parkinsonian symptoms. When this occurs, the condition may be referred to as Parkinson's Syndrome, or Atypical Parkinson's. For example, parkinsonian symptoms can be caused by tumors in the brain, repeated head trauma, prolonged use of tranquilizing drugs, and manganese and carbon monoxide poisoning. Even the commonly used drug, metoclopramide (Reglan), for stomach upset can cause parkinsonism. The disease is both chronic, meaning it persists over a long period of time, and progressive, meaning its symptoms grow worse over time. It is not contagious nor is it usually inherited. What Causes the Disease? Parkinson's Disease occurs when certain nerve cells, or neurons, in an area of the brain known as the Substantia Nigra become impaired or die. Dopamine is the normal chemical product produced by these neurons and acts as a chemical messenger responsible for transmitting signals between the Substantia Nigra and the next "relay station" of the brain, the Corpus Striatum. The Corpus Striatum acts to produce muscle activity. Loss of dopamine causes the nerve cells of the Striatum to fire out of control, leaving patients unable to direct or control their movements in a normal manner. There are many theories as to what causes cell death or impairment but the exact cause is still unknown.